What is Pazopanib in Cancer?

Pazopanib is a targeted therapy drug used in the treatment of various cancers. It works by inhibiting several vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and c-kit, which are involved in the formation of blood vessels (angiogenesis) and the growth of tumor cells. By blocking these receptors, Pazopanib effectively deprives tumors of the blood supply they need to grow and spread and Pazopanib Cost Philippines.

Common Uses of Pazopanib in Cancer:

Renal Cell Carcinoma (RCC):

Pazopanib is commonly used to treat advanced renal cell carcinoma (kidney cancer). It is often prescribed when the cancer is metastatic or has not responded to previous treatments. Pazopanib helps slow tumor growth and can sometimes shrink tumors by inhibiting blood vessels that supply oxygen and nutrients to the cancer.
Soft tissue sarcoma (STS):

Pazopanib is also used to treat advanced soft tissue sarcoma, especially when the cancer has spread to other parts of the body (metastatic sarcoma). It works similarly by blocking angiogenesis, which is necessary for tumor growth and spread.
Other potential uses:

Pazopanib is being studied for use in other types of cancers, including ovarian cancer and hepatocellular carcinoma (liver cancer), although its primary approved indications are for RCC and STS.
Mechanism of action:
Pazopanib is a tyrosine kinase inhibitor (TKI). It specifically targets and inhibits the activity of certain proteins involved in the process of angiogenesis:

VEGFR (vascular endothelial growth factor receptor)
PDGFR (platelet-derived growth factor receptor)
c-Kit (a receptor involved in the survival and proliferation of cells)
By blocking these receptors, pazopanib prevents the formation of new blood vessels (angiogenesis), which is a key step in the growth and spread of many tumors. Without an adequate blood supply, tumors become deprived of oxygen and nutrients, leading to slower growth or shrinkage.

Side effects of pazopanib:
Like many targeted therapies, pazopanib can cause side effects. Some of the most common side effects include:

Fatigue
Diarrhea
High blood pressure (hypertension)
Liver function abnormalities
Skin rashes
Loss of appetite
Hand-foot syndrome (redness, swelling, pain in the palms of the hands or soles of the feet)
Administration:
Pazopanib is taken orally in tablet form. It is usually prescribed to be taken once a day, with or without food. Patients are closely monitored for side effects during treatment, especially liver function, blood pressure, and heart health.

Summary:
Pazopanib is a targeted therapy used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcomas by inhibiting the growth of new blood vessels that supply tumors, slowing or stopping their growth. Despite being effective, it has some side effects that require careful monitoring by healthcare providers during treatment.

Website: Pazopanib Price in Malaysia